Pathology

We provide to the public and private scientific community the complete technical platform of a 150 m² laboratory, wich has the possibility to perform a great range of histopatologic techniques (fixation, parraffin embeeding, section, slides colouring, histopathologic and morphometric analisys). All used procedures are secured by a quality ensurance policy. High performance laboratory equipment allows us to safely proccess a great number of cases assuring at same time european standards quality.

Departamentul de Anatomie Patologică este implicat în activități de asigurare a calității țesuturilor utilizate în scop diagnostic și de cercetare prin urmărirea parametriilor de fază preanalitică.

Our department also carries the responsibility of a Biobank. Tissues are preserved either by paraffin embedding or frozen at -80°C. In our Biobank are stored normal and pathologic tissues that could be used for molecular testing and also for multicentric studies.

Molecular testing available in our department are “in situ” techniques which allow identification of proteins (immunohistochemistry) and nucleic acids DNA, RNA, microRNA (FISH, CISH) that have an important role in normal function of a tissue or in the etiology of different pathologies.

 

Molecular testing available in our department are “in situ” techniques which allow identification of proteins (immunohistochemistry) and nucleic acids DNA, RNA, , microRNA (FISH, CISH) that have an important role in normal function of a tissue or in the etiology of different pathologies.

Our department is involved in universitar and postuniversitar educational activities and research projects (bachelor, PhD, postdoctoral, postgraduate courses).

Presentation of the department

  • The Pathology Compartment of IMOGEN Research Center, began its activity in the beginning of 2015, with main interest in fetopathology and placental pathology.
  • The aim of anatomical pathology is to establish a precise diagnosis based on clinical data, macroscopic and microscopic examination. Its scope covers the whole human body and includes many types of pathology ( infection, inflammation, malformations and tumours).
    anatomie patologica microscop
  • Foetal autopsies are performed in order to determine cause of death, if is unknown (infectious, malformative, maternal pathology, etc.) or to confirm and characterize the anomalies identified or suspected. Foetal autopsies have an important role in genetic counselling regarding future pregnancies.
  • In the Pathology Compartment of IMOGEN Research Center, foetal autopsies are performed according to the gestational age of the embryo/foetus. Embryos and foetuses with gestational age under 20 weeks, macroscopic examination and even autopsy is made under stereomicroscope. For older foetuses the organs can be examined under stereomicroscope. This type of examination allows our specialists to diagnose malformations that otherwise would be difficult to observe.
    anatomie patologica
  • Tissue samples collected during autopsies and macroscopic examination of placenta and other biopsies, are examined by optical microscopy, using Haematoxylin-Eosin Stain. If it is needed Special Stains and Immunohistochemistry can be used.
  • Foetuses and placentas examined in the Pathology Compartment of IMOGEN Research Center are send to our service after spontaneous or therapeutic abortions in cases of suspected or confirmed malformations, or when a placental pathology is finded or suspected. Also we examine foetuses and placentas included in medical studies.
  • In special cases at IMOGEN Research Center we have the possibility to perform medical imaging of foetuses, examination that has a crucial role in diagnosis of certain malformations.
  • In the Pathology Compartment of IMOGEN Research Center, we have 2 Pathologists and one licensed nurse.