Imaging-Based Non-Invasive Diagnosis of Persistent Atrial Fibrillation – imATFIB
Programme: POC 2014-2020
PRIORITY AXIS 1 – RESEARCH, TECHNOLOGICAL DEVELOPMENT AND INNOVATION (RD&I) TO SUPPORT ECONOMIC COMPETITIVENESS AND BUSINESS DEVELOPMENT
ACTION 1.1.4 Attracting high-level personnel from abroad in order to enhance the RD capacity.
Project Type: Attracting high-level personnel from abroad.
Project identification number: P_37_245. Contract number: 23/01.09.2016, MySMIS code: 104004.
Project co-financed from the European Regional Development Fund through the Competitiveness Operational Programme 2014-2020.
Principal investigator: Dr. Zoltán Bálint
Total value: 8.554.261,25 RON , of which financial assistance grant: 8.469.565,25 RON. Source of the grant: FEDR – 7.151.700,8971 RON, BS – 1.317.864,3529 RON.
Implementation period: 01.09.2016 – 31.08.2020
Implementation places: IMOGEN Research Centre Cluj-Napoca, str. Pasteur f.n., postal code 400006 and County Emergency Hospital Cluj-Napoca, str. Clinicilor, nr. 3-5, postal code 400006, Cluj-Napoca, Cluj County, Romania.
Contact: Asistant manager – Dr. Cristiana Ciortea, Tel. 0264-597.852, e-mail: firstname.lastname@example.org.
General objective of the project:
Atrial fibrillation is the most common arrhythmia associated with substantial morbidity and mortality in humans. Histopathological studies of persistent atrial fibrillation have reported extracellular matrix remodelling with fibrotic infiltration which may cause atrial dilation. The degree of the fibrosis might have a significant impact on wave propagation during atrial fibrillation.
The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent atrial fibrillation. The result of the project is a diagnostic method which aids the medical work-up of patients suffering from the disease.
Primary objectives and expected results:
- Identification of the cause of persistent atrial fibrillation using correlation analysis of the imaging-derived parameters with the patient clinical data.
Expected result: Database and diagnostically relevant parameters aiding the diagnostic work-up..
- Development of an imaging- based method for anomaly localization and quantification in the fibrillating heart.
Expected result: Software for fibrosis quantification developed on the imaging data of the investigated patients.
- Investigation of the conductance of the affected heart to identify the contribution of the fibrotic region to the problems in wave propagation.
Expected result: Local physical properties of the fibrillating heart examined with functional MRI of the affected region on patients and healthy volunteers.
- Development of superparamagnetic magnetic resonance contrast agent with enhanced biocompatibility and low toxicity using a core/shell design.
Expected result: Nanoparticle-based contrast agent for MRI investigations.
Project launch imATFIB
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Conținutul acestui material nu reprezintă în mod obligatoriu poziția oficială a Uniunii Europene sau a Guvernului României.