Research

Our Company Vision

In the context of knowledge and experimental medicine, having as a central factor the assurance of human health, the IMOGEN Institute supports the sustainable development of society by promoting a favorable climate for research and innovation in the medical field by stimulating the research and the implementation in current medical practice of the results obtained.


Research Area 1: Obstetrics Gynecology

Research and studies dedicated to developing therapeutic guidelines to ensure optimal treatment of pregnancies affected by congenital syndromic and non-syndromic abnormalities;
Study and modeling of possible genetic mechanisms of occurrence of syndromic and non-syndromic abnormalities;
Studies and researches on the determination of the frequency of polymorphisms of genes with possible implications in the etiology of syndromic and non-syndrome congenital anomalies in the population of Transylvania
Research on the identification and study of possible risk factors in hereditary genetic diseases;
Studies and research on the identification of genetic risk markers and the evaluation of their frequency in the population, useful in understanding the etiology of congenital, syndromic and non-syndromic abnormalities, and development of prophylactic strategies, even from the intrauterine period;
Initiation of primary cultures of amniotic fluid and coral villites taken
Establishing a data bank (within a useful integrated information system) to underpin the development of the national registry of congenital malformations and the identification of the weight of the malformative and polymorphaform syndromes, of the actual incidence of genetic malformations;
Recording and updating data on the causes and mechanisms for producing morphogenesis errors;
Studies and research on pathological changes occurring in case of retardation of intrauterine development of the fetus and optimal conduct in this pregnant contingent;
Studies and research on the identification of levels of biological markers in order to improve perinatal morbidity indices in pregnancy with intrauterine growth retardation of the fetus;
Identification of the risk factors involved in the occurrence of fetal retardation, maintenance and worsening of the fetus’s intrauterine status (maternal anamnestic data, pregnancy-related pathology, fetal disease and pathology of fetal annexes) and correlation with the intensity of fetal-placental disorders;
Studies and research on the definition of retardation criteria for intrauterine fetal development by establishing the fetal growth pathway in the dynamics based on the use of the utero growth curves at the ultrasound examination.

Research Area 2: Medical Imaging

Research into the physiology of working memory, executive functions and emotions, imagistic and neuropsychological methods;
Research into the biological bases of human behavior;
Elaboration and standardization of new neuropsychological methods for investigation of mental processes;
Study of the etiopathogenesis of psychiatric disorders with the greatest socio-economic impact: depression, schizophrenia, drug addiction and dementia;
Early diagnosis of mental illness by characterizing the stages of onset of the disease;
Performing algorithms of radioimaging investigations to detect anatomopathological lesions and brain functional alterations so that they can accurately assess the state of the human psyche under pathological conditions (cognitions, emotions and behaviors);
Elaboration of minimally invasive methods for diagnostic imaging of diseases of the human psyche;
Elaboration of socio-professional recovery and socio-professional integration plans for psychiatric patients.

Research Area 3: Oro-maxilo-facial

Elaboration of a complex classification of clefts based on morphological and embryological criteria;

Embryological study on the appearance of splinters;
Develop a classification of complex congenital malformations based on morphological, embryological, genetic mutations;
Developing therapeutic protocols;
Study of rare labio-maxilo-palatine clefts;
In-depth cranio-maxillo-facial study of oro-facio-digital syndrome;
In-depth cranio-maxillo-facial study of the syndrome;
Opitz In-depth cranio-maxillofacial study of syndromes: Pierre-Robin.

Research Area 4: Neurology

Evaluating the role of CT in the diagnosis of brain or spinal lesions;
Assessment of the utility of CT in the diagnosis and treatment of diseases;
Assessment of the role of functional magnetic resonance in early diagnosis, including intrauterine, of various neurological disorders;
Comparative analysis of the data obtained and correlation of data obtained in the various stages of development, from fetus to elderly;
Introduction of functional MRI in diagnostic protocols of diseases with potential for neurological disability generation that could benefit from specific therapy or genetic counseling;
Evaluation of the utility of Doppler ultrasound in the diagnosis of various cerebral diseases;
Introduction of Doppler ultrasound in diagnostic protocols of cerebral diseases;
Diagnosing types of epilepsy as well as monitoring and monitoring treatment and development, also extremely useful in the diagnosis and monitoring of other brain disorders;
Evaluation of nerve and motor conduction velocities in disimmune or hereditary neuropathy for the detection of both proximal and distal conduction blocks and early treatment of motor multifocal neuropathy.